The Millennium Development Goals have garnered massive international support and mobilized new resources to improve conditions for the world's poorest. Much work remains to be done. We must redouble our efforts to ensure that we maintain progress while also laying the groundwork for addressing future global health challenges. And with the MDGs set to culminate in 2015, the global health community has its eye on the next wave of global health challenges, especially as the post-2015 debate moves to the country level. The 68th annual United Nations General Assembly provides a unique moment for the global health and diplomatic communities to help shape the next international development agenda.